USP7: NOVEL DRUG TARGET IN CANCER THERAPY

USP7: Novel Drug Target in Cancer Therapy

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation.Full activity of USP7 requires the Mini Plaque C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site to a catalytically competent state by the C-

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Evidence gaps in conservative non-pharmacological interventions and guideline implementation for high-burden non-communicable diseases: protocol for an overview of reviews

Non-communicable diseases (NCDs) represent a high burden for the society and affected individuals.Conservative non-pharmacological interventions play a first-line role in the treatment and management of most NCDs.Systematic reviews (SRs) provide the highest level of evidence and significantly influence clinical decision-making.The primary aim of th

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